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Bio-Techne corporation
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Sino Biological
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RayBiotech inc
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RayBiotech inc
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R&D Systems
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R&D Systems
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fluidigm
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fluidigm
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R&D Systems
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Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Article Title: Optimized Cellular Perfusate Increases Lung Viability Ex Vivo and Extends the Duration of Ex Vivo Lung Perfusion
doi: 10.1016/j.healun.2026.05.005
Figure Lengend Snippet: Lung injury markers during EVLP. (A) Perfusate PECAM-1, an endothelial injury marker, was significantly higher in STANDARD lungs than in DEVOL lungs across all time points (1 hour, p =*0.021; 6 hours, ** p <0.01; 12 hours, ** p <0.01). (B) Perfusate Syndecan-1, a proteoglycan indicative of glycocalyx degradation, was elevated in DEVOL lungs at 6 hours (** p <0.01; left). Syndecan-1 levels subsequently stabilized in DEVOL lungs but continued to rise in STANDARD lungs during extended perfusion (right). (C) No significant differences in perfusate LDH, a cytoplasmic marker of cellular damage, were observed between groups. (D) However, a strong trend toward higher HMGB-1, a damage-associated molecular pattern (DAMP), was detected in STANDARD lungs (two-way repeated-measures ANOVA: treatment, p =0.070).
Article Snippet: Additional biomarkers—including IL-17 (AFG Bioscience), TGFβ (R&D Systems), LDH (LSBio, Lynnwood, WA),
Techniques: Marker