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RayBiotech inc syndecan 1
Lung injury markers during EVLP. (A) Perfusate PECAM-1, an endothelial injury marker, was significantly higher in STANDARD lungs than in DEVOL lungs across all time points (1 hour, p =*0.021; 6 hours, ** p <0.01; 12 hours, ** p <0.01). (B) Perfusate <t>Syndecan-1,</t> a proteoglycan indicative of glycocalyx degradation, was elevated in DEVOL lungs at 6 hours (** p <0.01; left). Syndecan-1 levels subsequently stabilized in DEVOL lungs but continued to rise in STANDARD lungs during extended perfusion (right). (C) No significant differences in perfusate LDH, a cytoplasmic marker of cellular damage, were observed between groups. (D) However, a strong trend toward higher HMGB-1, a damage-associated molecular pattern (DAMP), was detected in STANDARD lungs (two-way repeated-measures ANOVA: treatment, p =0.070).
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Lung injury markers during EVLP. (A) Perfusate PECAM-1, an endothelial injury marker, was significantly higher in STANDARD lungs than in DEVOL lungs across all time points (1 hour, p =*0.021; 6 hours, ** p <0.01; 12 hours, ** p <0.01). (B) Perfusate <t>Syndecan-1,</t> a proteoglycan indicative of glycocalyx degradation, was elevated in DEVOL lungs at 6 hours (** p <0.01; left). Syndecan-1 levels subsequently stabilized in DEVOL lungs but continued to rise in STANDARD lungs during extended perfusion (right). (C) No significant differences in perfusate LDH, a cytoplasmic marker of cellular damage, were observed between groups. (D) However, a strong trend toward higher HMGB-1, a damage-associated molecular pattern (DAMP), was detected in STANDARD lungs (two-way repeated-measures ANOVA: treatment, p =0.070).
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Lung injury markers during EVLP. (A) Perfusate PECAM-1, an endothelial injury marker, was significantly higher in STANDARD lungs than in DEVOL lungs across all time points (1 hour, p =*0.021; 6 hours, ** p <0.01; 12 hours, ** p <0.01). (B) Perfusate <t>Syndecan-1,</t> a proteoglycan indicative of glycocalyx degradation, was elevated in DEVOL lungs at 6 hours (** p <0.01; left). Syndecan-1 levels subsequently stabilized in DEVOL lungs but continued to rise in STANDARD lungs during extended perfusion (right). (C) No significant differences in perfusate LDH, a cytoplasmic marker of cellular damage, were observed between groups. (D) However, a strong trend toward higher HMGB-1, a damage-associated molecular pattern (DAMP), was detected in STANDARD lungs (two-way repeated-measures ANOVA: treatment, p =0.070).
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Lung injury markers during EVLP. (A) Perfusate PECAM-1, an endothelial injury marker, was significantly higher in STANDARD lungs than in DEVOL lungs across all time points (1 hour, p =*0.021; 6 hours, ** p <0.01; 12 hours, ** p <0.01). (B) Perfusate <t>Syndecan-1,</t> a proteoglycan indicative of glycocalyx degradation, was elevated in DEVOL lungs at 6 hours (** p <0.01; left). Syndecan-1 levels subsequently stabilized in DEVOL lungs but continued to rise in STANDARD lungs during extended perfusion (right). (C) No significant differences in perfusate LDH, a cytoplasmic marker of cellular damage, were observed between groups. (D) However, a strong trend toward higher HMGB-1, a damage-associated molecular pattern (DAMP), was detected in STANDARD lungs (two-way repeated-measures ANOVA: treatment, p =0.070).
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fluidigm brigham
Lung injury markers during EVLP. (A) Perfusate PECAM-1, an endothelial injury marker, was significantly higher in STANDARD lungs than in DEVOL lungs across all time points (1 hour, p =*0.021; 6 hours, ** p <0.01; 12 hours, ** p <0.01). (B) Perfusate <t>Syndecan-1,</t> a proteoglycan indicative of glycocalyx degradation, was elevated in DEVOL lungs at 6 hours (** p <0.01; left). Syndecan-1 levels subsequently stabilized in DEVOL lungs but continued to rise in STANDARD lungs during extended perfusion (right). (C) No significant differences in perfusate LDH, a cytoplasmic marker of cellular damage, were observed between groups. (D) However, a strong trend toward higher HMGB-1, a damage-associated molecular pattern (DAMP), was detected in STANDARD lungs (two-way repeated-measures ANOVA: treatment, p =0.070).
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fluidigm 3145003b anti human cd160
Lung injury markers during EVLP. (A) Perfusate PECAM-1, an endothelial injury marker, was significantly higher in STANDARD lungs than in DEVOL lungs across all time points (1 hour, p =*0.021; 6 hours, ** p <0.01; 12 hours, ** p <0.01). (B) Perfusate <t>Syndecan-1,</t> a proteoglycan indicative of glycocalyx degradation, was elevated in DEVOL lungs at 6 hours (** p <0.01; left). Syndecan-1 levels subsequently stabilized in DEVOL lungs but continued to rise in STANDARD lungs during extended perfusion (right). (C) No significant differences in perfusate LDH, a cytoplasmic marker of cellular damage, were observed between groups. (D) However, a strong trend toward higher HMGB-1, a damage-associated molecular pattern (DAMP), was detected in STANDARD lungs (two-way repeated-measures ANOVA: treatment, p =0.070).
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R&D Systems human sdc1 recombinant protein
Lung injury markers during EVLP. (A) Perfusate PECAM-1, an endothelial injury marker, was significantly higher in STANDARD lungs than in DEVOL lungs across all time points (1 hour, p =*0.021; 6 hours, ** p <0.01; 12 hours, ** p <0.01). (B) Perfusate <t>Syndecan-1,</t> a proteoglycan indicative of glycocalyx degradation, was elevated in DEVOL lungs at 6 hours (** p <0.01; left). Syndecan-1 levels subsequently stabilized in DEVOL lungs but continued to rise in STANDARD lungs during extended perfusion (right). (C) No significant differences in perfusate LDH, a cytoplasmic marker of cellular damage, were observed between groups. (D) However, a strong trend toward higher HMGB-1, a damage-associated molecular pattern (DAMP), was detected in STANDARD lungs (two-way repeated-measures ANOVA: treatment, p =0.070).
Human Sdc1 Recombinant Protein, supplied by R&D Systems, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Lung injury markers during EVLP. (A) Perfusate PECAM-1, an endothelial injury marker, was significantly higher in STANDARD lungs than in DEVOL lungs across all time points (1 hour, p =*0.021; 6 hours, ** p <0.01; 12 hours, ** p <0.01). (B) Perfusate Syndecan-1, a proteoglycan indicative of glycocalyx degradation, was elevated in DEVOL lungs at 6 hours (** p <0.01; left). Syndecan-1 levels subsequently stabilized in DEVOL lungs but continued to rise in STANDARD lungs during extended perfusion (right). (C) No significant differences in perfusate LDH, a cytoplasmic marker of cellular damage, were observed between groups. (D) However, a strong trend toward higher HMGB-1, a damage-associated molecular pattern (DAMP), was detected in STANDARD lungs (two-way repeated-measures ANOVA: treatment, p =0.070).

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Article Title: Optimized Cellular Perfusate Increases Lung Viability Ex Vivo and Extends the Duration of Ex Vivo Lung Perfusion

doi: 10.1016/j.healun.2026.05.005

Figure Lengend Snippet: Lung injury markers during EVLP. (A) Perfusate PECAM-1, an endothelial injury marker, was significantly higher in STANDARD lungs than in DEVOL lungs across all time points (1 hour, p =*0.021; 6 hours, ** p <0.01; 12 hours, ** p <0.01). (B) Perfusate Syndecan-1, a proteoglycan indicative of glycocalyx degradation, was elevated in DEVOL lungs at 6 hours (** p <0.01; left). Syndecan-1 levels subsequently stabilized in DEVOL lungs but continued to rise in STANDARD lungs during extended perfusion (right). (C) No significant differences in perfusate LDH, a cytoplasmic marker of cellular damage, were observed between groups. (D) However, a strong trend toward higher HMGB-1, a damage-associated molecular pattern (DAMP), was detected in STANDARD lungs (two-way repeated-measures ANOVA: treatment, p =0.070).

Article Snippet: Additional biomarkers—including IL-17 (AFG Bioscience), TGFβ (R&D Systems), LDH (LSBio, Lynnwood, WA), Syndecan-1 (Ray Biotech, Norcross, GA), and HMGB-1 (LSBio)—were measured using individual ELISA kits.

Techniques: Marker